The Science of Prevention

The Science of Prevention
Do’s and Don’ts that Could Save Your Life!

Running, Exercising Outdoors

The key to living a healthy, balanced life is practicing prevention. Benjamin Franklin said, “an ounce of prevention is worth a pound of cure.”

If you are not already well versed in your family medical history, I can not stress the importance of having those conversations. If someone in your immediate family has a chronic illness like heart disease, high cholesterol, diabetes, or a history of cancer, this is something both you & your doctor should be aware of.

There are basically two types of inherited disease: single gene inheritance & multifactorial (or complex) inheritance. Examples of single gene inheritance are diseases like cystic fibrosis and sickle cell anemia. In those instances, there are no changes that you can make to your environment or you lifestyle to impact whether or not you will develop these diseases. Multifactorial inherited diseases are a different story. Examples of these are things like diabetes, high blood pressure, and even cancer. If you inherited a risk factor for one of these types of diseases, taking preventive steps in your life could be difference between developing the disease or not.

Having regular physicals with your health care provider & scheduling recommended preventive screenings for high blood pressure, high cholesterol, breast cancer, colorectal cancer, ovarian cancer, and even depression could save your life. Many of these diseases, when detected early, can be treated with medication or in some cases even with simple lifestyle changes like diet and exercise.

Other preventive measures that are important for a healthy lifestyle and in some cases could save your life include:

Not smoking
Getting to & maintaining a healthy weight
Being physically active
Consuming a healthy diet
Not drinking excessively

I’m curious … are there diseases that you know of that run in your family that you could prevent or help your children or loved ones prevent with these tips? Comment below & tell me about it.

If you can’t remember the last time you had that physical or “annual” mammogram, schedule it NOW! Then come back to this page and tell me, “I did it!”

Drug Sensitivity and Genetics: What You Need to Know and Share with Your Doctor

 

At some point in our lives, we are all more than likely going to be prescribed medications to treat an acute or chronic illness.  The way each of our bodies responds to drugs is different, and our genes play a role in this.  The science that predicts a response to drugs based on genetics is pharmacogenomics.

If you have ever read the labeling information about a new or existing drug that you or a family member have been prescribed, you have likely read about possible adverse events (side effects).  Pharmaceutical companies are starting to include pharmacogenomic data in their products’ labeling.  If you have had genetic testing done, the results can help your health care provider choose an appropriate drug therapy for you, as well as determine what an appropriate starting dose would be for those with sensitivities.

If you haven’t had genetic testing done, drug response information from your immediate family
members can be helpful for your doctor to know as well.  Talk to your siblings and parents about their health history. Tell you health care providers if you are discussing drug treatment and you have had personal genetic testing done. Likewise if you are aware of a certain drug sensitivity or positive response to a drug of a sibling or parent.

According to the Food and Drug Administration, there is an ongoing need for physicians to  educate themselves about pharmacogenomics.  If your physician is dismissive when you attempt to share this important information, you may need to look for a doctor who values informed patients who want to take an active role in their health care decisions.

 

 

Tips for Finding Relatives Quickly and Easily on 23andMe and Improving Your Odds That They Return Contact

I am a member of the 23andMe community.  For those of you not aware of 23andme, they are a personal genetic testing company located in Mountain View, California not far from my home.
If you are interested in wellness and in science (which I assume you are if you have found my blog!), then check out their site to learn more about their service.I tweeted today about how I had been able to find three 23andMe users with whom I had determined our relationships.  What I found really interesting was that the four of us are scattered around the world and didn’t see a link initially based on our last names or our listed surnames.  While our ages ranged from 30s to 80s, we all ended up being related via the same family line!

My tweet received a reply from a 23andMe member who wanted to know if I had any tips on how to make the Relative Finder process less intimidating.  For example, when I log in, I can see 352 people who are predicted third cousins to “distant” cousins.  Most are just listed as “Male” or “Female,” so unless a member has made their profile public it can be tough to decide where to begin.  A second tweet came shortly after from @akhomenko via Twitter asking me to share my tips widely.  Seemed a perfect topic for today’s blog, so here goes!

Tip #1 — Go for the Low-hanging Fruit!
Log in to the service and navigate to Relative Finder.
At the top, you will see an option to sort your list in a variety of ways.
Select “Sort by Last Name”.  This will bring you all of the users with public profiles to whom there is a predicted relationship.  Scan the list of names to see if anything rings a bell and go from there.  If nothing looks familiar to you, then select the person who has the highest percentage of DNA in common with you.  I have found that members with public profiles are more responsive to direct messages and tend to share more in their profiles.  When you invite someone to share genomes make sure to customize the message!  Receiving a message that looks like it was written by a computer program is about as exciting as opening junk mail at home.  I find that I get the greatest response when I make the other party curious enough to answer my message.  Make it personal!  I might say something like this:

Hi Jennifer,

23andMe has identified us as potential 3rd cousins with .24% DNA in common, so we are definitely related.  I’d like to share stories with you to see if we can determine how we are related.  I hope to hear from you soon.

Thanks,

Karen

Tip #2 — Sort by Percent Shared
Still in Relative Finder, select “Sort by Percent Shared” from the drop-down menu.
Now you are going to see those members with whom you share the most DNA.  In my case, many of these are NOT public profiles, so you have to start out by sending an introductory message.  Again, customizing the message will increase the likelihood that the other person writes you back because you have peaked their curiousity.  For folks in this category, I started by those with whom I shared the greatest percentage of DNA.  The person at the top of my list and I shared .76% DNA, and we were quick to determine how we were related after sharing surnames.  With some of the other connections, I’ve really had to go through my family tree database (which luckily I had handed down to me by a first cousin of my grandmother that I met randomly via Ancestry.com!)

This should get you started making a few initial connections.  In my next post, I will talk about how you can use the Compare Genes and Family Inheritance features to help you even further.

Enjoy the weekend!
Karen